I will provide an update on our research into the most diverse spiders (infraorder Araneomorphae) and scorpions (family Buthidae). The exceptional diversity of araneomorph spiders is mirrored by their remarkably versatile venom arsenal. I will discuss our progress in characterizing the toxin content of buthids and several araneomorph families that have evolved to produce very distinct venoms being rich in either small molecules, linear or disulfide-rich peptides, or proteins. I will highlight our attempts to (i) develop analgesics based on purotoxins from spider venoms that inhibit P2X receptors and (ii) characterize the insect-selective ion channel ligands from arachnids.
This work was supported by the grant of the state program of the “Sirius” Federal Territory “Scientific and technological development of the ‘Sirius’ Federal Territory” (Agreement no. 35-03 of 26.08.2026).