Oral 9th Venoms to Drugs 2026

Artificial Intelligent Aided Discovery and Action Mechanism Study of Conopeptides Targeting nAChR (147534)

Rilei Dr Yu 1
  1. Ocean University of China, Qingdao, SHANDONG, China
Publish consent withheld
  1. Zhang J, Yin Z, Li Y, Ge C, Zhang Z, Yuan P, Jiang T, Craik DJ, Zhao Y*, Yu R*. Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor. Acta Pharm Sin B. 2026 Jul;16(7):4147-4165.
  2. Ge C, Tae HS, Lu L, Zhang Z, Huang Z, An B, Wang Y, Jiang T, Cai W, Chang S, Adams DJ, Yu R. A deep learning framework (CreoPep) for target-specific design and optimization of conotoxin peptides. Commun Chem. 2026 Jan 9;9(1):82.
  3. Yin Z, Song X, Zhou Y, Qin Z, Yuan P, Wang C, Wang C, Jiang T, Yu R*. Discovery and Optimization of a Monodisulfide Conotoxin Defines a Potent and Selective α9α10 nAChR Blocker with Analgesic Efficacy. J Med Chem. 2026 Mar 12;69(5):5913-5924.
  4. Li X, Tae HS, Chen S, Yousuf A, Huang L, Zhang J, Jiang T, Adams DJ*, Yu R*. Dual Antagonism of α9α10 nAChR and GABAB Receptor-Coupled CaV2.2 Channels by an Analgesic αO-Conotoxin Analogue. J Med Chem. 2024 Jan 13. doi: 10.1021/acs.jmedchem.3c00979.
  5. Li T, Tae HS, Chen S, Li X, Liang J, Pan T, Zhang Z, Jiang T, Adams DJ, Yu R*. Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain. J Med Chem. 2024 Nov 14;67(21):18741-18752.
  6. Li X, Zhou S, Tae HS, Wang S, Li T, Cai W, Jiang T, Adams DJ*, Yu R*. N-Terminal Capping of the αO-Conotoxin Analogue GeX-2 Improves the Serum Stability and Selectivity toward the Human α9α10 Nicotinic Acetylcholine Receptor. J Med Chem. 2024 Oct 24;67(20):18400-18411.